Emetine - Wikipedia
网页Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root. It takes its name from its emetic properties. [1]
Synthesis in the Emetine Series. XIII.1 Structure and Synthesis of ...
网页This article is cited by 12 publications. Takashi Itoh,, Michiko Miyazaki,, Hiromi Fukuoka,, Kazuhiro Nagata, and, Akio Ohsawa. Formal Total Synthesis of (−)-Emetine Using Catalytic Asymmetric Allylation of Cyclic Imines as a Key Step.
Emetine induces oxidative stress, cell differentiation and NF-κB ...
网页2024年4月29日 · Emetine is an FDA-approved antiparasitic drug with antitumor properties; however, little is known about its potential against LSCs. Herein, we explored the antileukemic potential of emetine,...
Different Aspects of Emetine’s Capabilities as a Highly Potent …
网页2022年6月6日 · Emetine can disrupt the SARS-CoV-2 mRNA binding with eIF4E and decrease viral RNA production and protein synthesis. Actually, emetine exerts part of its anti-SARS-CoV-2 activity by the modulation of the ERK/MNK1/eIF4E signaling pathway, a critical target applied for viral replication in the host cells.
Different Aspects of Emetine’s Capabilities as a Highly Potent …
网页2022年5月23日 · In the global movement to find the appropriate agents to fight the coronavirus disease of 2019 (COVID-19), emetine is one of the strongest anti-SARS-CoV-2 compounds with sub-micromolar EC 50 values, identified in several studies and high-throughput screening efforts.
Synthesis in the emetine series—XIV - Semantic Scholar
网页Synthesis in the emetine series—XIV. A. Brossi, H. Bruderer, +1 author. S. Teitel. Published 1968. Chemistry. Tetrahedron. View via Publisher. Save to Library. Create Alert. Cite. 11 Citations. Citation Type. More Filters.
Emetine Is Not Ipecac: Considerations for Its Use as Treatment for …
网页2020年11月27日 · Emetine was an important and effective anti-infective drug for the treatment of intestinal and extraintestinal amoebiasis, between the mid-1910s to the 1970s. It was likely administered to 10s–100s of millions of people in the treatment of amoebiasis (see Supplementary File).
Synthesis in the Emetine Series XV1) Friedel-Crafts Acylation of N ...
网页Benzo[a] quinolizidines are important intermediates in the synthesis of Ipecac alkaloids3 and several representatives of this class are useful therapeutic agents.4,5,6,7,8 We would like to report a...
Emetine Is Not Ipecac: Considerations for Its Use as Treatment …
网页2020年11月10日 · While emetine is a “pure drug” as it is extracted from ipecac, some of the differences between emetine and ipecac are also discussed. Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity.
Chapter 3 The Ipecac Alkaloids - ScienceDirect
网页1971年1月1日 · Mass spectrometry has played a major role in the elucidation of the structures of protoemetinol, ankorine, demethylpsychotrine, demethyltubulosine, alangicine, deoxytubulosine, tubulosine, isotubulosine, alangimarkine, and alangamide.