Interleukin 15 - Wikipedia
网页Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132).
Interleukin 15: A key cytokine for immunotherapy - PubMed
网页IL-15 serves multiple functions including dictating T cell response, regulating tissue repair and B cell homing, modulating inflammation, and activating NK cells. Among cytokines, IL-15 is unique because of its wide expression, tightly regulated secretion, trans-presentation, and therapeutic potential.
白介素15(IL-15)的作用机制、生物学功能及应用！ - 知乎
网页2024年1月8日 · 白细胞介素-15（interleukin -15，IL-15）是一种T细胞生长因子，于1994年被两个独立的实验室发现，与IL-2具有类似的生物学功能。IL-15 主要由单核细胞和巨噬细胞产生。人体多种组织表达 IL-15 mRNA, 如心、肺、肾…
白细胞介素15 (IL-15)的作用机制、生物学功能及应用
网页白细胞介素-15（interleukin -15，IL-15）是一种T细胞生长因子，于1994年被两个独立的实验室发现，与IL-2具有类似的生物学功能。IL-15 主要由单核细胞和巨噬细胞产生。
The role of Interleukin-15 in inflammation and immune responses …
网页Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.
Therapeutic potential of interleukin-15 in cancer (Review)
网页2021年4月24日 · The role of immunotherapy is to trigger the immune system to recognize and destroy tumor cells. Interleukin-15 (IL-15) is a member of the common gamma-chain (γc) cytokines that promote the differentiation and expansion of T cells, B cells and natural killer (NK) cells, leading to enhanced antitumor responses.
Interleukin 15: A key cytokine for immunotherapy - ScienceDirect
网页2016年10月1日 · IL-15 is a critical modulator for ensuring the host defence against intracellular pathogens. • IL-15 is not only involved in maintaining the naïve, effector and memory T cells, but also play a predominant role in reactivation of memory T cells. •
The biology of interleukin-2 and interleukin-15: implications for ...
网页2006年8月1日 · Interleukin-2 (IL-2) and IL-15 have both similar and contrasting functional roles in the life and death of lymphocytes. The heterotrimeric receptors for these cytokines have two subunits in...
Molecular Pathways: Interleukin-15 Signaling in Health and in …
网页2014年4月4日 · Interleukin-15 (IL-15) is a pro-inflammatory cytokine involved in the development, survival, proliferation and activation of multiple lymphocyte lineages utilizing a variety of signaling pathways. IL-15 utilizes three distinct receptor chains in at least two different combinations to signal and exert its effects on the immune system.
IL-15/IL-15 receptor biology: a guided tour through an expanding ...
网页The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of …
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