Activators and Inhibitors of Protein Kinase C (PKC): Their …
网页2021年10月20日 · Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or non-classic PKC isozymes (nPKCs; δ, ε, …
Protein kinase C - Wikipedia
网页In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
PKC 通路 | Cell Signaling Technology
网页蛋白激酶 c (pkc) 家族成员调控大量的细胞反应，包括基因表达、蛋白分泌、细胞增殖和炎性反应。 其基本的蛋白结构包括一个 N 端调节区，该调节区由一个铰链区连接至 C 端激酶区域。
Protein Kinase C Beta - an overview | ScienceDirect Topics
网页The protein kinase C (PKC) pathway plays an important role in the regulation of RANKL mRNA expression in osteoblasts. Thus, phorbol-12-myristate-13-acetate (PMA), an activator of the PKC pathway and of various transmembrane protein shedding, stimulates osteoclast differentiation by an induction of RANKL expression by osteoblasts.
Protein kinase C: A potential therapeutic target for endothelial ...
网页2023年9月1日 · Protein kinase C (PKC) is a family of serine/threonine protein kinases that play an important role in many organs and systems and whose activation contributes significantly to endothelial dysfunction in diabetes.
5579 - Gene ResultPRKCB protein kinase C beta [ (human)]
网页Protein kinase Calpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways. PKC-beta-dependent augmentation of transcellular ISC-cAMP at the level of the basolateral membrane demonstrated that transport events with geographically distinct subcellular membranes can …
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to …
网页2022年1月13日 · Attenuation of the PKCβII–ACSL4 pathway effectively blocks ferroptosis in vitro and impairs ferroptosis-associated cancer immunotherapy in vivo. Our results identify PKCβII as a sensor of lipid...
PKC Pathway | Cell Signaling Technology
网页Protein kinase C (PKC) family members regulate numerous cellular responses including gene expression, protein secretion, cell proliferation, and the inflammatory response. The basic protein structure includes an N-terminal regulatory region connected to a C-terminal kinase domain by a hinge region.
Protein kinase C-beta gene variants, pathway activation, and ...
网页Background: Protein kinase C-beta2 (PKCbeta2) is a splice-variant of the PRKCB1 gene and belongs to a family of serine/threonine-specific kinases that are predominantly activated by diacylglycerol, calcium, and phorbol ester. Cellular functions associated with PKCbeta2 activation include transformation, proliferation, and inhibition of apoptosis.
Protein Kinase C Beta - an overview | ScienceDirect Topics
网页Protein Kinase C Beta (PKC-β) is a serine/threonine kinase that plays a crucial role in regulating cell signaling pathways, particularly in glioma cells. It is involved in cell growth, survival, and response to certain treatments, making it a potential target for therapeutic interventions in malignant glioma.