Pharmacological effects of berberine on mood disorders
WEBNov 18, 2018 · At a low dose, berberine (10 and 20 mg/kg) is effective in depression by increasing levels of NE, 5‐HT and DA. 18 In contrast, high doses of berberine (100, 500 mg/kg) decreased concentrations of biogenic amines. 18, 79 Furthermore, berberine increased the concentrations of their metabolites in the brain stem.
Current Evidence and Future Directions of Berberine Intervention …
WEBMay 23, 2022 · A recent study showed that berberine was involved in the regulation of depression progression through miRNA and BDNF. Berberine treatment could effectively reverse the promotion effect of overexpression of miR-34b-5p/miR-470-5p on the depressive-like behavior of chronic unpredicted mild stress (CUMS) mice and regulate the growth of hippocampal ...
Research progress on antidepressant effects and mechanisms of berberine
WEBJan 22, 2024 · This review summarizes the evidence of pharmacological applications of berberine in treating depression and elucidates the mechanisms of berberine regulating neurotransmitter levels, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal axis dysfunction, anti-oxidative stress, and suppressing inflammatory ...
Berberine: Is it a Promising Agent for Mental Disorders Treatment?
WEBAmple evidence reported that berberine had been associated with CNS-related disorders, including Alzheimer's, cerebral ischemia, mental depression, schizophrenia and anxiety. Thus, in this review, we aimed to indicate the effectiveness of berberine on …
Berberine exerts antidepressant effects in vivo and in vitro …
WEBJan 1, 2024 · Behavioral tests and levels of neurotransmitters proved that berberine could effectively ameliorate depression-like symptoms in CRS mice.
Berberine attenuates depression-like behavior by modulating the ...
WEBOct 1, 2023 · Abstract. Objective. Increasing evidence suggests that inflammation appears to play a role in the genesis of depression. Berberine has potent anti-inflammatory effects and potential antidepressant activity, although the …
Pharmacological effects of berberine on mood disorders
WEBNov 18, 2018 · At a low dose, berberine (10 and 20 mg/kg) is effective in depression by increasing levels of NE, 5-HT and DA. 18 In contrast, high doses of berberine (100, 500 mg/kg) decreased concentrations of biogenic amines. 18, 79 Furthermore, berberine increased the concentrations of their metabolites in the brain stem.
Berberine ameliorates depression-like behaviors in mice via …
WEBMar 1, 2023 · Neuroinflammation has been suggested that affects the processing of depression. There is renewed interest in berberine owing to its anti-inflammatory effects. Herein, we investigated whether berberine attenuate depressive-like behaviors via inhibiting NLRP3 inflammasome activation in mice model of depression.
Research progress on antidepressant effects and mechanisms of berberine
WEBJan 22, 2024 · This review summarizes the evidence of pharmacological applications of berberine in treating depression and elucidates the mechanisms of berberine regulating neurotransmitter levels, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal axis dysfunction, anti-oxidative stress, and suppressing inflammatory ...
Current Evidence and Future Directions of Berberine ... - PubMed
WEBMay 23, 2022 · There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has …