1. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S2211383522005184

    Berberine ameliorates chronic kidney disease through inhibiting …

    • At present, clinical interventions for chronic kidney disease are very limited, and most patients rely on dialysis to sustain their lives for a long time. However, studies on the gut–kidney axis have shown that the gu… 展开

    1. Introduction

    Kidney disease is a global public health problem, affecting more than 750 million people … 展开

    ScienceDirect
    2. Materials and methods

    2.1. Chemicals and reagents
    Berberine hydrochloride was purchased from J&K Scientific Co., Ltd. (Beijing, China). Trimethylamine oxide, sodium butyrate, adenin… 展开

    ScienceDirect
    3. Results

    3.1. BBR ameliorated adenine-induced CKD in rats
    The experimental scheme was shown in Fig. 1A. Rat-maintained feed with supplement of 0.… 展开

    ScienceDirect
    4. Discussion

    CKD is a serious threat to human health. With the progression of CKD, renal toxins increasingly accumulate in the human body and cannot be excreted by kidneys. Most of these renal toxin… 展开

    ScienceDirect
    5. Conclusion

    In this study, the therapeutic effect of BBR on CKD was investigated, and BBR was revealed to deplete gut-derived uremic toxins and improve the structure of the intestinal flora in … 展开

    ScienceDirect
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    目录
    1. Introduction
    2. Materials and methods
    3. Results
    4. Discussion
    5. Conclusion
    Is berberine a renoprotective agent in diabetic nephropathy?
     
  1. Several scholars have found that BBR has promising renoprotective effects against different renal illnesses, including diabetic nephropathy, renal fibrosis, renal ischemia, renal aging, and renal stones. Also, it has renoprotective effects against nephrotoxicity induced by chemotherapy, heavy metal, aminoglycosides, NSAID, and others.

    Protective effects of berberine on various kidney diseases: Empha…

    www.sciencedirect.com/science/article/pii/S0024320522003976
    www.sciencedirect.com/science/article/pii/S0024320522003976
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    Can berberine help treat chronic kidney disease?
    Meanwhile, berberine increased the butyric acid producing bacteria and the butyric acid content in feces, while decreased the renal toxic trimethylamine N -oxide. These findings suggest that berberine may be a therapeutic drug with significant potential to ameliorate chronic kidney disease through the gut–kidney axis.

    Berberine ameliorates chronic kidney disease through inhibiting the

    sciencedirect.com
    What is berberine used for?
    Berberine (BBR) is one of the main active components of the traditional Chinese medicine Coptidis Rhizoma, which is currently used in the clinic to treat intestinal infections. In recent years, it was reported that BBR has therapeutic effects on metabolic diseases, such as hyperlipidemia, hyperglycemia, etc. 25, 26, 27, 28, 29.

    Berberine ameliorates chronic kidney disease through inhibiting the

    sciencedirect.com
    Is berberine a renoprotective agent in diabetic nephropathy?
    Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized to exert renoprotective effects in DN progression. However, the action mechanism of BBR in DN remains to be fully understood.

    Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB p…

    biolres.biomedcentral.com
    Does berberine protect against cisplatin-induced kidney damage?
    Domitrovic R, Cvijanovic O, Pernjak-Pugel E, Skoda M, Mikelic L, Crncevic-Orlic Z. Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis. Food Chem Toxicol. 2013;62:397–406.

    Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB p…

    biolres.biomedcentral.com
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  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393204

    Berberine protects against diabetic kidney disease via promoting …

  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326381

    Effect of Berberine on Hyperuricemia and Kidney Injury: A Network ...

  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov/31734944

    Berberine protects against diabetic kidney disease via ... - PubMed

  6. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0024320522003976

    Protective effects of berberine on various kidney diseases: …

  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov/35718235

    Protective effects of berberine on various kidney diseases

  8. ScienceDirect
    https://www.sciencedirect.com/science/article/abs/...

    Protective effects of berberine on various kidney diseases: …

  9. Taylor & Francis Online
    https://www.tandfonline.com/doi/full/10.108…

    Full article: Berberine protects diabetic nephropathy by …

    网页Accumulating evidence has implicated that berberine (BBR) has a beneficial effect on diabetic kidney disease (DKD), but its mechanism is not clear. The aim of this study was to assess whether berberine could alleviate …

  10. Wiley Online Library
    https://bpspubs.onlinelibrary.wiley.com/doi/f…

    Berberine protects against diabetic kidney disease via …

    网页2019年11月16日 · Our present findings have revealed the important role of berberine in regulating kidney energy homeostasis and protecting glomerular podocytes from metabolic stress, and have identified …

  11. Biological Research
    https://biolres.biomedcentral.com/article…

    Berberine ameliorates diabetic nephropathy by …

    网页2018年3月31日 · Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized to exert …

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