Updated Diagnostic Criteria and Classification of Mast Cell …
网页2021年10月13日 · In the case of atypical lesions or a negative Darier’s sign, the diagnosis of mastocytosis can still be established provided that minor criteria are fulfilled. In young children with typical mastocytoma, testing for the Darier’s sign is often avoided because of the risk to provoke systemic reactions.
Darier’s sign in mastocytosis - American Society of Hematology
网页2014年2月20日 · Unlike other forms of dermatographism, Darier’s sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP.
Mastocytosis and Mast Cell Activation Disorders: Clearing the Air
网页2021年10月19日 · Darier’s sign is a physical examination feature of mastocytosis described as the formation of a wheal in response to rubbing, scratching, or stroking of the skin. Darier’s sign is present in most cases of mastocytosis affecting the skin, although the absence of Darier’s sign does not rule out a diagnosis [ 60 ].
Urticaria Pigmentosa - StatPearls - NCBI Bookshelf
网页2023年11月13日 · Darier’s sign is the formation of a wheal upon stroking or rubbing skin lesions and suggests the diagnosis of cutaneous mastocytosis. The wheal forms due to the release of mast cell mediators, which can contribute to the systemic symptoms that may occur after stroking the lesion.
Mastocytosis - DermNet
网页Cutaneous mastocytosis is usually diagnosed by its clinical appearance and positive Darier sign, in the absence of systemic symptoms and signs. Patients with a solitary mastocytoma generally require no further workup. Skin biopsy and histology can be helpful for confirmation of cutaneous mastocytosis.
Updated Diagnostic Criteria and Classification of Mast Cell ...
网页2021年8月3日 · In the case of atypical lesions or a negative Darier’s sign, the diagnosis of mastocytosis can still be established provided that minor criteria are fulfilled. In young children with typical mastocytoma, testing for the Darier’s sign is often avoided because of the risk to provoke systemic reactions.
Darier's Sign - an overview | ScienceDirect Topics
网页Most patients with mastocytosis exhibit Darier's sign, which is the development of an urticarial wheal and flare after firm stroking of lesional skin. This cutaneous finding represents the response to physical disruption of the granular contents of mast cells, particularly histamine.
Pediatric Mastocytosis: Recognition and Management
网页2021年1月25日 · The Darier sign is usually positive in pediatric patients with mastocytosis. In young children with a large mastocytoma or nodular lesions, testing for the Darier sign should be avoided or performed very gently, as it can potentially provoke flushing or even hypotension [4, 32].
Darier's sign - Wikipedia
网页Darier's sign is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria pigmentosa. [1] In general, the skin becomes swollen, itchy and red. This is a result of compression of mast …
Mastocytosis (cutaneous and systemic) in adults ... - UpToDate
网页2024年7月11日 · Mastocytosis describes a group of rare disorders in which there is pathologic accumulation of mast cells in tissues. These diseases can be limited to the skin (cutaneous mastocytosis [CM]) or involve extracutaneous …