Histamine H2 receptor - Wikipedia
网页H2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G s alpha subunit.
H2 Blockers - StatPearls - NCBI Bookshelf
网页2024年8月11日 — H2 receptor blockers, or H2 receptor antagonists (H2RAs), are gastric acid-suppressing agents frequently used in various gastric conditions. The FDA approves these drugs to treat uncomplicated gastroesophageal reflux disease (GERD), gastric or duodenal ulcers, gastric hypersecretion, and mild to infrequent heartburn or indigestion.
Histamine Type-2 Receptor Antagonists (H2 Blockers)
网页2018年1月25日 — The H2 receptor blockers act by binding to histamine type 2 receptors on the basolateral (antiluminal) surface of gastric parietal cells, interfering with pathways of gastric acid production and secretion. The selectivity of H2 blockers is of key importance, as they have little or no effect on the histamine type 1 receptors, which are blocked ...
What to Know About H2 Receptor Blockers for GERD - WebMD
网页2021年12月1日 — H2 receptor blockers are drugs that are used to treat gastroesophageal reflux disease (GERD) and peptic ulcers. This drug is effective, cheap, and safe for relieving heartburn.
H2 receptor antagonist - Wikipedia
网页receptor antagonist. Ball-and-stick model of cimetidine, the prototypical H 2 receptor antagonist. H2 antagonists, sometimes referred to as H2RAs[1] and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H 2 receptors of the parietal cells in the stomach.
Histamine H2 Receptor - an overview | ScienceDirect Topics
网页The H2 receptor is encoded for on chromosome 5 and relies not only the phosphoinositide metabolic pathway but also the adenylate cyclase system that uses cAMP as a mediator. H2-receptor stimulation leads to gastric acid secretion, inotropic and chronotropic cardiac stimulation, and downregulation of the immune system.
Histamine H2 Receptor - an overview | ScienceDirect Topics
网页Histamine receptor 2 (HR2) activation mediates early desensitization of basophils. The initial decrease in basophil activity is also associated with symptom scores in grass pollen immunotherapy. H2R suppresses allergen-associated FcεRI-mediated basophil activation. HR2 mainly plays a role in immune tolerance mechanisms.
Biochemistry, Histamine - StatPearls - NCBI Bookshelf
网页2023年5月1日 — This class of drugs blocks the actions of histamine at the H2 receptor sites in the parietal cells of the stomach, thereby decreasing the production of gastric acid. H2 antihistamines have been therapeutic agents in the treatment of a variety of conditions such as peptic ulcers, gastroesophageal reflux disease (GERD), and dyspepsia.
Histamine receptors, agonists, and antagonists in health and disease
网页Four G-protein-coupled receptors mediate the effects of histamine. Two of these receptors, H3 and H4 receptors, are high-affinity receptors in the brain and immune system, respectively. The two classic histamine receptors, H1 receptor and H2 receptor, are well known as drug targets for allergy and gastric ulcer, respectively.
Histamine H1 and H2 receptors are essential transducers of the ...
网页2021年4月14日 — To study the effects of H 1 /H 2 blockade on the hemodynamic response during and after interval cycling exercise, healthy adults performed a single exercise session with either placebo (control) or H 1 /H 2 antagonist intake (blockade) on separate days in a randomized and single-blinded design (Fig. 1A and table S1).