The Roles of Mast Cells in Parasitic Protozoan Infections
网页2017年4月6日 · Mast cells (MCs) are known to be central players in allergy and anaphylaxis, and it has been demonstrated that MCs have crucial roles in host defense against a number of different pathogens, including parasites. To date, there are many studies that have examined the interaction of helminth-derived antigens and MCs.
Mast Cell: A Multi-Functional Master Cell - PMC - National Center …
网页2016年1月6日 · Mast cells are involved in the regulation of variety of physiological functions, including vasodilation, angiogenesis, bacterial, and parasite elimination. In addition, mast cells regulate functions of many cell types, such as dendritic cells, macrophages, T cells, B cells, fibroblasts, eosinophils, endothelial cells, and …
The Multifaceted Roles of Mast Cells in Immune Homeostasis, …
网页2022年2月17日 · Mast cells are usually activated via the surface-type receptors, including Toll-like receptors (TLRs), major histocompatibility complexes MHCs (class I and II), complement receptors (CR1-5, C3aR, and C5aR), cytokine receptors (IL-1R, IL-3R, IL-10R IL-12R, INFγR, TGFβR, and MRGPRX2), and chemokine receptors (CCR1, CCR3, CCR4, CCR5, CCR7, CXCR1 ...
Mast Cells, Mastocytosis, and Related Disorders | NEJM
网页2015年7月9日 · Mast cells develop from hematopoietic progenitors in response to stem-cell factor (KIT ligand), which is the ligand of the CD117 transmembrane tyrosine kinase receptor, encoded by KIT. CD117...
The Role of Mast Cells in the Defence against Pathogens
网页2012年4月26日 · Mast cell–derived cytokines and chemokines can enhance the migration of dendritic cells (DCs; TNF-α and CCL20) and effector T cells (CXCL10/IP10 and CCL5/RANTES) to the site of infection and to draining lymph nodes. Mast cells can also function directly as antigen-presenting cells, particularly for CD8 + …
Frontiers | Responses of Mast Cells to Pathogens: Beneficial and ...
网页Mast cells (MCs) are strategically located in tissues close to the external environment, being one of the first immune cells to interact with invading pathogens. They are long living effector cells equipped with different receptors that allow microbial recognition.
The Roles of Mast Cells in Parasitic Protozoan Infections
网页2017年4月6日 · We offer a general review of the data from patients and experimental animal models infected with the aforementioned protozoa, which correlate MCs and MC-derived mediators with exacerbated inflammation and disease progression as well as protection against the parasitic infections in different circumstances.
Mast Cells and Basophils: From Malevolent Design to Coevolutionary Arms ...
网页2020年5月21日 · Mast cells and basophils are central to acquired resistance against blood-feeding arthropods which, in turn, counteract these cells by modulating their biological activities.
Understanding human mast cells: lesson from therapies for
网页2021年10月5日 · In this Review, we discuss the existing and emerging therapies that target mast cells, and we consider how these treatments can help us to understand mast cell functions in disease.
Insights into the Characteristics and Functions of Mast Cells in
网页2023年12月5日 · Mast cells have vital functions in allergic responses and parasite ejection, while the underlying mechanisms remain unclear. Meanwhile, MCs are essential for the maintenance of GI barrier function, and their interactions with neurons, immune cells, and epithelial cells have been related to various gastrointestinal (GI) disorders.
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