Nicotine - Wikipedia
网页Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) [9] and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms.
Nicotine | Tobacco, Addiction, Poison | Britannica
网页2024年8月30日 · nicotine, an organic compound that is the principal alkaloid of tobacco. (An alkaloid is one of a group of nitrogenous organic compounds that have marked physiological effects on humans.) Nicotine occurs throughout the tobacco plant and especially in the leaves. The compound constitutes about 5 percent of the plant by weight.
Nicotine - American Chemical Society
网页2018年8月20日 · Nicotine is an unusual alkaloid in that it has two nitrogen-containing heterocycles, pyridine and pyrrolidine. It is, of course, the tobacco component that makes smoking highly addictive, leading to the consequence that …
Nicotine Chemistry, Metabolism, Kinetics and Biomarkers
网页Nicotine (Fig. 1) is a natural ingredient acting as a botanical insecticide in tobacco leaves. It is the principal tobacco alkaloid, occurring to the extent of about 1.5% by weight in commercial cigarette tobacco and comprising about 95% of the total alkaloid content.
Nicotine: From Discovery to Biological Effects - PMC
网页2023年9月26日 · The α3β4 nAChR is thought to mediate the cardiovascular effects of nicotine, while α7 is the most abundant in non-neuronal cells and mediates nicotine’s biological effects, such as cell proliferation, neo-angiogenesis, and resistance to drug-induced apoptosis.
Nicotine and Related Alkaloids: Absorption, distribution, …
网页Nicotine is an alkaloid which is present, together with a number of minor alkaloids, in tobacco and a wide variety of other plants. The introduction of tobacco as a therapeutic agent against diverse pathologi cal and physiological conditions resulted in the widespread exposure of people to nicotine, and the subsequent recognition of the ...
Nicotine | C10H14N2 | CID 89594 - PubChem
网页Nicotine | C10H14N2 | CID 89594 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Nicotine Chemistry, Pharmacology, and Pharmacokinetics
网页2016年1月1日 · This chapter describes the basic chemical structure and function of nicotine, the major alkaloid found in tobacco. Structurally related to the endogenous neurotransmitter ACh, nicotine exerts a variety of stimulatory and inhibitory actions mediated by nAChRs ubiquitously expressed throughout the body.
Molecular modeling of major tobacco alkaloids in mainstream cigarette ...
网页2016年7月15日 · Whereas nicotine is the most abundant alkaloid, accounting for approximately 95 % of alkaloid content, the other alkaloids (β-nicotyrine, 3,5-dimethyl-1-phenylpyrazole, pyridine, and 3-methylpyridine) have been shown to exhibit biological activity resulting to serious cellular damage, heart disease, and respiratory illnesses .
Tobacco nicotine uptake permease (NUP1) affects alkaloid metabolism
网页2011年11月1日 · NUP1 belongs to a plant-specific class of purine uptake permease-like transporters that originated after the bryophytes but before or within the lycophytes. NUP1 expressed in yeast cells preferentially transported nicotine relative to other pyridine alkaloids, tropane alkaloids, kinetin, and adenine.