Telomeres and telomerase: three decades of progress
网页2019年2月13日 · Three decades ago, the classic view was that telomeres protected the natural ends of linear chromosomes and that telomerase was a specific telomere-terminal transferase necessary for the...
Telomerase: structure, functions, and activity regulation
网页Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes and stem and tumor cells.
Telomerase: Definition, Function, Structure and Cancer - Biology …
网页2017年7月25日 · Telomerase is an enzyme found inside our cells, which may be related to the aging process. It adds short, repetitive “caps” to our DNA strands. These caps are called “telomeres.”
Regulation of human telomerase in homeostasis and disease
网页2020年4月2日 · Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR), which serves...
Telomeres and human disease: ageing, cancer and beyond
网页2005年8月1日 · Telomerase is a cellular reverse transcriptase that synthesizes de novo telomeric repeats at chromosome ends. Most somatic tissues lack telomerase activity and show progressive telomere...
Structural biology of telomeres and telomerase
网页2019年11月14日 · Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to counter telomere shortening. Human telomeres are composed of complexes between telomeric DNA and a six-protein complex known as shelterin.
Detailed view of human telomerase enzyme invites rethink of
网页2018年4月25日 · The telomerase enzyme performs a crucial role by maintaining protective caps of repetitive DNA sequences at the ends of chromosomes. A structure of human telomerase casts fresh light on its ...
Structural biology of telomeres and telomerase - PubMed
网页Telomeres are protein-DNA complexes that protect chromosome ends from illicit ligation and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to counter telomere shortening.
Telomerase: Structure, functions, and activity regulation - Springer
网页2011年1月14日 · Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes and stem and tumor cells. In human somatic cells proliferation potential is strictly limited and senescence follows approximately 50–70 cell divisions.
Telomerase - SpringerLink
网页2023年3月31日 · Telomerase is a specialized RNA-protein enzyme that synthesizes telomeric DNA repeats onto the G-rich single-stranded 3′-overhang of telomeres. The enzyme complex contains a reverse transcriptase catalytic protein and a stably associated RNA component that...
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